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Molly Maloof, MD

Director of Clinical Content
@DoctorBase

miserable

amitriptylinamitriptyline for 1MONTH....after that...my skin was itching so bad and red welts would appear and dissappear with in a few minutes after scratching...it's very irritating. ..it's hard to get a good night sleep when that happens. ..what can I do
Poster
  • Female | 39 years old
  • Complaint duration: 30 days
  • Medications: None at this moment
  • Conditions: No

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Amitriptyline (also known as Elavil) is prescribed for various purposes, often at bedtime. Skin reactions are sometimes a side effect or allergic reaction caused by this medication. The reaction you are experiencing sounds like a form of urticaria called dermatographia. It might resolve, but may be an indication that you are allergic or sensitive to this medication. I advise you to call your doctor as soon as possible.
Jorge A. Sabin
If you are having welts the same width of your nails after scratching this is called dermatographic urticaria or skin writing. This is a bit unusual because amitriptyline has some strong antihistamine properties that should decrease allergic welts. If the welts are wide and round then you are probably allergic to the drug and possibly allergic to others in the same family of tricyclic medications. Call your doctor and ask to try a different type of medication for your initial symptoms.
Theodore Christou
There is a strong possibility that you could be developing allergic reaction to the drug. The Tricyclics (Amitriptyline belongs to that family of drugs) also can cause generalized dryness of the skin (xerosis). Many a times the allergic reactions also involve mucus membranes. Are there any ulcers in your mouth? Why was this drug given to you? The first step is to STOP the drug. As Dr. Browning has recommended take Zyrtec/Allegra etc. If you do not clear your symptoms within 48 hours then consult your physician.
Jamil Hussain
You might want to try a Zyrtec every morning and Benadryl at night. I hope you feel better quickly.
Since the symptoms are temporally related to starting Amitriptyline, it is very likely that you are experiencing a medication reaction. The appearance of welts would suggest an urticarial reaction. 1. Stop the medication. 2. take an OTC antihistamine such as Claritin or Zyrtec. 3. A hydro-cortisone lotion or SARNA may help with the itching.

4. See your doctor.
James Sandwich
It sounds like you're allergic to the medication you took. Try taking Benadryl OTC. If that doesn't work. see your Family Physician and let him examine you and he may consider steroids. If all else fails, ask your doctor to refer you to a dermatologist.

Carey :M Delcau, MD

Family Physician

St. Louis, MO
Carey M Delcau
It seems like you have an adverse reaction to amitryptilline. Please see your internist or a dermatologist. You probably will have your medication stopped and switched to an alternative.
stay away from that drug as it is the probable cause of your hives. If breathing problems develop call 911. At this time try over the counter Zytec or generic cetirizine 10 mg once or twice daily. Avoid aspirin and ibuprofen [Nsaid] like drugs as they may aggravate this reaction. Stop eating or drinking artificially colored foods or drinks, especially those with red , yellow, orange , or green dyes. And no shrimp or shellfish at this time. If the problem ldoesn't resolve promptly[one week] or worsens , see your Dermatologist or Allergist.
Alan Semion
Allergic reaction Stop advise benadryl 25 to 50 q 6 h. No driving. Aveeno Oatmeal bath in "hot" not. Boiling water bath. Appointment w MD within 1 to 3 days.
George Moskowitz
Stop the medication and take Benadryl and call your doctor who prescribed it for an appointment

Thanks
Robby T. Ayoub