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coombs positive

I am coombs positive. what would happen if my blood comes in contact with someone elses?
Poster
  • Female | 28 years old

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Featured Answer

1 UpVoted this answer
If you are Coombs positive, that means your blood serum contains antibodies against red blood cells, be they your own or those of other people. So, when your blood is exposed to that of another person, your serum antibodies will attack their red blood cells causing the blood to clump or agglutinate. What this means is that your blood be not be transfusion into other people even if you belong to the same blood group. Also if get pregnant and your serum antibodies come into contact with your baby's red blood cells, they may be destroyed, leading to intrauterine death. This is similar to what happens when you have Rh negative blood and your baby has Rh positive blood. The production of these antibodies can be suppressed with steroids as needed, or the recipient's blood can be totally replaced under critical conditions. I hope this is not too much information for your simple question.
1 UpVoted this answer Otumdi Omekara, MD Preventive Medicine Specialist, Portland
Since there are many causes of a positive Coombs test and since there are two different tests, it is hard to say. You probably should not donate blood, and if you become pregnant there will likely need to be some extra care for you and your baby. I am not sure exactly what you mean by "if my blood comes in contact with someone else's" The Web MD web site has some excellent information on Coombs testing as does Mayo Clinic Online. You should also talk to your physician.
(Revised Answer)

If you are Coombs positive, that means your blood serum contains antibodies against red blood cells, be they your own or those of other people. So, when your blood is exposed to that of another person, your serum antibodies will attack their red blood cells causing the blood to clump or agglutinate. What this means is that your blood can not be transfusion into other people even if you belong to the same blood group. Also, if you get pregnant and your serum antibodies come into contact with your baby's red blood cells, they may be destroyed, leading to intrauterine death. This is similar to what happens when you have Rh negative blood and your baby has Rh positive blood. The production of these antibodies can be suppressed with steroids as needed, or the recipient's blood can be totally replaced under critical conditions. I hope this is not too much information for your simple question.
Nothing. In a transfusion, the lab would do testing to assure compatibility and prevent a reaction.