Ketamine is a type of Psychedelic Anesthetic Recreational Drug - its chemical structure is similar to that of Phencyclidine (PCP or Angel Dust).
Ketamine is (rarely) used as a Pharmaceutical Anesthetic.
Ketamine may cause Euphoria in many users and may cause Hallucinations.
By activating PCP Receptors located within the body's N-Methyl-D-Aspartate (NMDA) Receptors, Ketamine may interfere (block) the normal function of the body's NMDA Receptors (this mechanism is the underlying process by which Ketamine attains its biochemical effects within the body). When PCP Receptors are activated, they antagonize the actions of Aspartic Acid, Glutamic Acid and N-Methyl-D-Aspartate, preventing the normal activation of NMDA Receptors - substances that activate PCP Receptors "plug" the Ion Channel of the NMDA Receptor, preventing Calcium Ion influx.
Ketamine may cause long-lasting Psychosis that has required hospitalization in some users...

Depression cannot be addressed by just medical drugs (Rx) alone. Depression should be addressed through a combination of psycho-therapy, dietary recommendations, exercize, spirituality and cultural community involvements and meditation(such as Yoga)...

They to effective treatment of depression is to determine the underlying cause of the depression. That can vary from person to person. No physician should use the same Rx for all patients to treat depression. Depression triggered by breaking up a relationship or loosing a loved one should not be treated in the same manner as depression triggered by a food Allergy or dietary issues or that is triggered from a persons physical circumstance(such as being injured and no longer being able to play your favorite game or do something you love doing)... All of these are different underlying causes and must be addressed according to its specific circumstances... Trying to treat these three with the same method is not going to produce effective results in some, while it may work perfect with others.... Psychotherapy would not be an effective first line of treatment for a food Allergy that is triggering depression, and drugs that only deal with symptoms is not going to truly address the emotional nor physical needs of patients long term. In fact many pharmacuetical drugs contribute to increasing the risk of mental health disease, including phyical disease..Yes there are anti-depressants that cause depression.. Thus Integrative Medicine and the holistic approach is the most effective way to address depression in all of its many forms. The goal should be always try to find a way to stop the depression, not suppress it. As suppression can lead to long term chronic health problems later in life.

Shalomim Y HaLahawi