These are both great products to soften the nasolabial folds (the parentheses lines around your mouth). I often prefer a thicker product for deeper folds - either Perlane or Juvederm Ultra Plus. These both now come pre-mixed with lidocaine for a more comfortable patient experience. Some patients may also benefit from adding volume to the cheeks as well. By volumizing the cheek, you also get softening of the nasolabial folds and a youthful, natural look.